These Scientists Created a Functional 'Designer' Chromosome
Jennifer Paul — April 2, 2014 — Tech
References: med.nyu.edu & sciencerecorder
A group of researchers from New York University decided to take on the field of genetics in a very different way by creating a designer chromosome. They are building an entire chromosome from scratch. The team used a computer to construct a purely synthetic structure that is based off a chromosome that can be found in the brewer's yeast Saccharomyces cerevisiae.
Scientists, along with a host of undergraduate students, stitched short strands of DNA to complete the chromosome. This was a very time-consuming task, taking about seven years to complete. The project is part of a global initiative called Sc2.0. It aims to eventually be able to fabricate all of the yeast's chromosomes. So far, the focus has been on the smallest chromosome in the genome. This is the first time a chromosome has been developed for a 'eukaryote.'
Scientists, along with a host of undergraduate students, stitched short strands of DNA to complete the chromosome. This was a very time-consuming task, taking about seven years to complete. The project is part of a global initiative called Sc2.0. It aims to eventually be able to fabricate all of the yeast's chromosomes. So far, the focus has been on the smallest chromosome in the genome. This is the first time a chromosome has been developed for a 'eukaryote.'
Trend Themes
1. Synthetic Genomics - Creating functional chromosomes using synthetic DNA strands presents opportunities for custom designing genetic material for various applications.
2. Biotechnology Advancements - The development of designer chromosomes opens up possibilities for advancements in the field of biotechnology, allowing for tailored genetic modifications in organisms.
3. Organism Engineering - Building custom-made chromosomes through synthetic biology could revolutionize the field of organism engineering, enabling the creation of organisms with desired characteristics.
Industry Implications
1. Biotechnology - The biotechnology industry can leverage synthetic genomics to develop innovative products and applications with custom-designed genetic material.
2. Pharmaceuticals - Pharmaceutical companies can explore the potential of designer chromosomes to develop new drugs and therapies by precisely modifying the genetic makeup of organisms.
3. Agriculture - The agricultural industry can benefit from organism engineering using designer chromosomes to create crops with enhanced traits, such as improved yield, resistance to pests, and adaptation to environmental conditions.
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